A report on sickle cell anemia causes and effects on the human body

ShareCompartir Only in some individuals do malaria episodes progress to severe life-threatening disease, while in the majority the episodes are self-limiting. This is partly because of host genetic factors such as the sickle cell gene. The sickle cell gene is caused by a single amino acid mutation valine instead of glutamate at the 6th position in the beta chain of the hemoglobin gene. Inheritance of this mutated gene from both parents leads to sickle cell disease and people with this disease have shorter life expectancy.

A report on sickle cell anemia causes and effects on the human body

Sickle cell anemia Sickle cell anemia Normal red blood cells are round. In sickle cell anemia, some red blood cells become deformed, so they look like sickles used to cut wheat.

These unusually shaped cells give the disease its name. Sickle cell anemia is an inherited form of anemia — a condition in which there aren't enough healthy red blood cells to carry adequate oxygen throughout your body.

Normally, your red blood cells are flexible and round, moving easily through your blood vessels. In sickle cell anemia, the red blood cells become rigid and sticky and are shaped like sickles or crescent moons. These irregularly shaped cells can get stuck in small blood vessels, which can slow or block blood flow and oxygen to parts of the body.

There's no cure for most people with sickle cell anemia. But treatments can relieve pain and help prevent problems associated with the disease.

Sickle cell anemia - Symptoms and causes - Mayo Clinic

Symptoms Signs and symptoms of sickle cell anemia, which vary from person to person and change over time, include: Sickle cells break apart easily and die, leaving you without enough red blood cells.

Red blood cells usually live for about days before they need to be replaced. But sickle cells usually die in 10 to 20 days, leaving a shortage of red blood cells anemia.

Without enough red blood cells, your body can't get the oxygen it needs to feel energized, causing fatigue. Periodic episodes of pain, called crises, are a major symptom of sickle cell anemia.

A report on sickle cell anemia causes and effects on the human body

Pain develops when sickle-shaped red blood cells block blood flow through tiny blood vessels to your chest, abdomen and joints. Pain can also occur in your bones. The pain varies in intensity and can last for a few hours to a few weeks. Some people have only a few pain episodes.

Others have a dozen or more crises a year. If a crisis is severe enough, you might need to be hospitalized. Some adolescents and adults with sickle cell anemia also have chronic pain, which can result from bone and joint damage, ulcers and other causes.

Painful swelling of hands and feet. The swelling is caused by sickle-shaped red blood cells blocking blood flow to the hands and feet. Sickle cells can damage an organ that fights infection spleenleaving you more vulnerable to infections.

Doctors commonly give infants and children with sickle cell anemia vaccinations and antibiotics to prevent potentially life-threatening infections, such as pneumonia.

Red blood cells provide your body with the oxygen and nutrients you need for growth. A shortage of healthy red blood cells can slow growth in infants and children and delay puberty in teenagers.

Tiny blood vessels that supply your eyes may become plugged with sickle cells. This can damage the retina — the portion of the eye that processes visual images, leading to vision problems.Sickle cell disease (also called sickle cell anemia) is an inherited blood disorder that affects red blood cells.

The sickle cell gene causes the body to produce abnormal hemoglobin. In sickle cell disease, the hemoglobin clumps together, causing red blood cells to become stiff .

Sickle cell anemia - Symptoms and causes - Mayo Clinic

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The inset image shows a cross-section of a normal red blood cell with normal hemoglobin. Figure B shows abnormal, sickled red blood cells blocking blood flow in a blood vessel. The inset image shows a cross-section of a sickle cell with abnormal (sickle) hemoglobin forming rigid strands.

Sickle cell anemia, also called sickle cell disease (SCD), is an inherited disorder that leads to the production of abnormal forms of hemoglobin S (Hb S or Hgb S). Sickle cell tests are used to diagnose sickle cell anemia, identify people with sickle cell trait, and treat complications.

What Is a Sickle Cell Crisis? their shape lets them move easily throughout your body. But when you have sickle cell disease (SCD), “Sickle Cell Anemia.”.

A report on sickle cell anemia causes and effects on the human body

Sickle cell disease is caused by an abnormal type of hemoglobin called hemoglobin S. Hemoglobin is a protein inside red blood cells that carries oxygen. Hemoglobin S changes the red blood cells.

The red blood cells become fragile and shaped like crescents or sickles.

Sickle Cell Disease | Johns Hopkins Medicine Health Library